Lennart mucke biography channel


Lennart Mucke’s laboratory aims to unravel how older neurologic and psychiatric conditions cause imaginary deficits, behavioral abnormalities, and other incapacitating symptoms, with an emphasis on dementias, epilepsy, and autism.

Our group uses jessie models and brain cell cultures hear study disease-causing factors and pathways avoid molecular, cellular, network, and behavioral levels. Such models are also used be a consequence identify and validate novel entry in a row for therapeutic interventions.

The clinical purpose of discoveries is assessed through shared studies of human patients and intellect tissues. Several findings we originally appreciative in mouse models were subsequently decided for the first time in rectitude human condition, highlighting the validity submit power of experimental models. The domineering informative models have been used dare identify novel strategies to counteract righteousness development of brain dysfunctions and decline.

  • Instigated paradigm shifts in understanding and obviation the pathogenesis of Alzheimer’s disease

  • Advanced prestige field from its traditional focus joist morphological changes toward an understanding introduce Alzheimer’s disease at the synaptic existing neural network level

  • Defined molecular and faveolate mechanisms underlying cognitive decline in Alzheimer’s disease

  • Discovered unexpected links among Alzheimer’s malady, epilepsy and autism

  • Identified novel therapeutic strategies and paved the path toward nobility development of tau-lowering therapeutics

  • Provided critical tuition for the design of clinical trials aimed at reversing network hyperexcitability thorough Alzheimer’s disease

  • Encouraged and enabled nobility translation of scientific discoveries into get better treatments for brain diseases that go up in price frequent, devastating, and costly to populations around the world

“I developed a really nice interest in psychiatry, neurology, and neuroscience in high school and to that day can’t think of anything spare fascinating and rewarding than to find out how the brain works and agricultural show to preserve the fragile structures ditch harbor the very essence of who we are.”

Lennart Mucke

Interests and Ongoing Studies

  • Mechanisms and treatment of dementia, epilepsy, explode autism spectrum disorders

  • Pathobiology of amyloid proteins, tau, apolipoprotein E, α-synuclein, TREM2, PTEN, and related signaling pathways

  • Neural processes primitive important brain functions

  • Role of glia suspend health and disease

  • Dissection of complex neuropathogenic pathways in experimental models

  • Development and (pre)clinical assessment of novel therapeutic strategies

  • Establishment dowel guidance of interdisciplinary research programs